주요 연구 분야

융합 의학

회춘(노화방지)

줄기세포와 그 보금자리

혈관신생과 염증

면역학

연구 내용

본 연구실의 궁극적인 목표는 줄기세포 기반 융합 연구를 통해 재생의학의 개념적 진보와 획기적인 발견을 이루고자 한다. 우리의 신체를 이루는 수많은 세포와 기관들은 질병과 나이가 들어감에 따라 그 기능이 현저히 감소한다. 따라서, 우리의 연구 목표는 첫째, 손상된 세포와 기관들을 정상 상태로 회복시키는 것이며, 둘째 , 이러한 손상된 세포와 기관을 젊은 상태로 되돌리는 기전을 밝히고자 한다. 이를 위해 본 연구실은 줄기세포와 주변 미세환경과의 상호작용, 고형암을 포함한 기능장애 기관의 혈관신생 및 염증 조절 기전을 밝히는데 중점을 두고 있다.

주요 연구 업적

1. PPAR-δ agonist affects Adipo-chondrogenic differentiation of human Mesenchymal Stem Cells through the expression of PPAR-γ. Kim DH, Kim DH, Heck BE, Shaffer M, Yoo KH, Hur J. Regenerative Therapy. 2020 Dec;15:103-111.

2. A natural supplement formula reduces anti-oxidative stress and enhances osteochondrogenic differentiation potential in mesenchymal stem cells. Kim DH, Kim DH, Bruce E. Heck. Michael Shaffer. Hur J*. Yoo KH*. J Clin Biochem Nutr. 2020 May;66(3):206-212. * co-corresponding author

3. Prognostic Role of Zinc Finger Homeobox 4 in Ovarian Serous Cystadenocarcinoma. Ha M, Kim J, Park SM, Hong CM, Han ME, Song P, Kang CD, Lee D, Kim YH, Hur J*, Oh SO*. Genet Test Mol Biomarkers. 2020 Mar;24(3):145-149. * co-corresponding author.

4. Ex vivo expansion of regulatory T cell and T helper 2 cells using a hematosphere culture. Kim DH, Song P, Han JH, Hur J. Immunobiology. 2020 Feb 22:151918.

5. Rabbit palatum-derived mesenchymal progenitor cells tri-lineage differentiation on 2D substrates and 3D printed constructs. Kim DH, Kim BY, Kim DH, Hur J,* Baek CH.* J Appl Biomater Funct Mater. 2019 Jul;17(3). * co-corresponding author.

6. KAI1(CD82)-DARC(CD234) axis in the stem cell niche. Jin Hur et. al. Cell Cycle. 2016 Aug 2;15(15):1945-7.

7. CD82/KAI1 Maintains the Dormancy of Long-Term Hematopoietic Stem Cells through Interaction with DARC-Expressing Macrophages. Jin Hur*, Jae-Il Choi* et. al. Cell Stem Cell. 2016 Apr 7;18(4):508?21. * co-first authors

8. Priming mobilized peripheral blood mononuclear cells with the “activated platelet supernatant” enhances the efficacy of cell therapy for myocardial infarction of rats. Kang J*, Hur J*, Kang JA*. Cardiovascular Therapeutics. 2016 Aug;34(4):245-53. * co-first authors

9. M-CSF from Cancer Cells Induces Fatty Acid Synthase and PPARβ/δ Activation in Tumor Myeloid Cells, Leading to Tumor Progression. Park J*, Lee SE*, Hur J*, et. al. Cell Rep. 2015 Mar 10;10(9):1614-25. * co-first authors.

10. Human podoplanin-positive monocytes and platelets enhance lymphangiogenesis through the activation of the podoplanin/CLEC-2 axis. Hur J*, Jang JH*, Oh IY*. et.al. Mol Ther. 2014 Aug;22(8):1518-29. * co-first authors.

11. Erythropoietin priming improves the vasculogenic potential of G-CSF mobilized human peripheral blood mononuclear cells. Kang J*, Yun JY*, Hur J*, et. al. Cardiovasc Res. 2014 Oct 1;104(1):171-82. * co-first authors.

12. Activated platelet supernatant can augment the angiogenic potential of human peripheral blood stem cells mobilized from bone marrow by G-CSF. Kang J*, Hur J*, Kang JA*, et. al. J Mol Cell Cardiol. 2014 Oct;75:64-75. * co-first authors

13. Highly angiogenic CXCR4(+)CD31(+) monocyte subset derived from 3D culture of human peripheral blood. Hur J*, Choi JI*, Yun JY*, et. al. Biomaterials. 2013 Mar;34(8):1929-41. * co-first authors

14. New method to differentiate human peripheral blood monocytes into insulin producing cells: Human hematosphere culture. Hur J*, Yang JM*, et. al. Biochem Biophys Res Commun. 2012 Feb 24;418(4):765-9. * co-first authors

15. Human peripheral blood-born hematosphere as a niche for hematopoietic stem cell expansion. Hur J*, Park J*, Lee SE*, et. al. Cell Res. 2011 Jun;21(6):987-90. * co-first authors.

16. Identification of a Novel Role of T cells in Postnatal Vasculogenesis : Characterization of Endothelial Progenitor Cell Colonies. Jin Hur*, Han-Mo Yang*, Chang-Hwan Yoon*, et. al. Circulation. 2007 Oct 9;116(15):1671-82.

17. Akt Is a Key Modulator of Endothelial Progenitor Cell Trafficking in Ischemic Muscle. J. Hur*, C.-H. Yoon*, et. al. Stem Cells. 2007 July; 25(7):1769-78.

18. Intercellular Adhesion Molecule-1 Is Upregulated in Ischemic Muscle, Which Mediates Trafficking of Endothelial Progenitor Cells. Chang-Hwan Yoon*, Jin Hur*, et. al. Arterioscler Thromb Vasc Biol. 2006 May;26(5):1066-72. * co-first authors.

19. Synergistic Neovascularization by Mixed Transplantation of Early Endothelial Progenitor Cells and Late Outgrowth Endothelial Cells. Chang-Hwan Yoon*, Jin Hur*, et. al. Circulation. 2005 Sep 13;112(11):1618-27. * co-first authors.

20. Augmentation of Therapeutic Angiogenesis Using Genetically Modified Human Endothelial Progenitor Cells with Altered Glycogen Synthase Kinase-3 Activity. Jin-Ho Choi*, Jin Hur*, et. al. J. Biol. Chem. 2004 Nov 19;272(47):49430-8. * co-first authors.

Characterization of Two Types of Endothelial Progenitor Cells and Their Different Contributions to Neovasculogenesis. Jin Hur*, Chang-Hwan Yoon*, et. al. Arterioscler Throm