주요 연구 분야

줄기세포, 재생의학, 니쉬, 암, 혈관생물학

연구 내용

본 연구실에서는 조혈모줄기세포 조절(Hematopoietic stem cell regulation), 미세환경(Niches), 혈액암(Blood cancer) 및 고형암(Solid cancer) 등의 암의 발병 및 전이과정에 중요한 암줄기세포(Cancer stem cell), 혈관 발생 및 분화 등을 중심으로 중개 의학에 중점을 두고 있음. 특히 줄기 세포 조절과 혈액 질환을 정의하고 정보를 활용하여 새로운 치료법을 개발하고, 특히 정상 조혈 및 혈액 악성 종양에서 새로운 유전자의 기능 특성화를 목표로 하고 있음. 

주요 연구 업적

1. Lee D*, Park C*, Lee H, Lugus JJ, Kim SH, Arentson E, Chung YS, Gomez G, Kyba M, Lin S, Janknecht R, Lim DS, and Choi K. ER71 acts downstream of BMP, Notch, and Wnt signaling in blood and vessel progenitor specification. Cell Stem Cell. 2008 2 (5): 497-507. doi:10.1016/j.stem.2008.03.008. IF: 20.860. *Equal contribution.

2. Wang YH, Israelsen WJ, Lee D, Yu VWC, Jeanson NT, Clish CB, Heiden MV, Cantley LC,

and Scadden DT. Cell-State-Specific Metabolic Dependency in Hematopoiesis and Leukemogenesis. Cell. 2014 158 (6): 1309-1323. doi:10.1016/j.cell.2014.07.048. IF: 38.637.

3. Lee D, Wang YH, Kalaitzidis D, Ramachandran J, Eda H, Sykes DB, Raje N and Scadden DT. Endogenous transmembrane protein UT2 inhibits pSTAT3 and suppresses hematological malignancy. J Clin Invest. 2016 126 (4): 1300-1310. doi:10.1172/JCI84620. IF: 11.864.

4. Silberstein L, Goncalves KA, Kharchenko PV, Turcotte R, Kfoury Y, Mercier F, Baryawno N, Severe N, Bachand J, Spencer J, Papazian A, Lee D, Chitteti BR, Srour E, Hoggatt J, Tate T, Celso CL, Ono N, Nutt S, Heino J, Sipila K, Shioda T, Osawa M, Lin CP, Hu G and Scadden DT. Proximity-based differential single cell analysis of the niche to identify stem/progenitor cell regulators. Cell Stem Cell. 2016 19 (4): 530-543. doi:10.1016/j.stem.2016.07.004. IF: 20.860.

5. Sykes DB, Kfoury Y, Mercier F, Wawer M, Law J, Haynes M, Lewis T, Schajnovitz A, Jain E, Lee D, Meyer H, Pierce K, Tolliday N, Waller A, Ferrara S, Eheim A, Stoeckigt D, Maxcy K, Cobert J, Bachand J, Szekely B, Mukherjee S, Sklar L, Kotz J, Clish C, Sadrayev R, Clemons P, Janzer A, Schreiber S and Scadden DT. Inhibition of dihydroorotate dehydrogenase overcomes differentiation blockade in acute myeloid leukemia. Cell. 2016 167 (1): 171-186. doi:10.1016/j.cell.2016.08.057. IF: 38.637

6. Lee D*, Kalaitzidis D*, Efeyan A, Kfoury Y, Nayyar N, Sykes DB, Mercier FE, Papazian A, Baryawno N, Victora GD, Neuberg D, Sabatini DM and Scadden DT. Amino acid-insensitive mTORC1 regulation enables nutritional stress resilience in hematopoietic stem cells. J Clin Invest. 2017 127 (4): 1405-1413. doi:10.1172/JCI89452. IF: 11.864. *Equal contribution.

7. Lee DH, Kim TS, Lee D† and Lim DS†. Mammalian sterile 20 kinase 1 and 2 are important regulators of hematopoietic stem cells in stress condition. Sci Rep. 2018 8: 942. doi:10.1038/s41598-018-19637-y. IF: 3.998. †Corresponding authors.

8. S?v?re N, Karabacak NM, Gustafsson K, Baryawno N, Courties G, Kfoury Y, Kokkaliaris KD, Rhee C, Lee D, Scadden EW, Garcia-Robledo JE, Brouse T, Nahrendorf M, Toner M and Scadden DT. Stress-Induced Changes in Bone Marrow Stromal Cell Populations Revealed through Single-Cell Protein Expression Mapping. Cell Stem Cell. 2019 25 (4): 570-583. doi: 10.1016/j.stem.2019.06.003. IF: 20.860.

9. Baryawno N, Przybylski D, Kowalczyk MS, Kfoury Y, Severe N, Gustafsson K, Kokkaliaris KD, Mercier F, Tabaka M, Hofree M, Dionne D, Papazian A, Lee D,, Ashenberg O, Subramanian A, Vaishnav ED, Rozenblatt-Rosen O, Regev A and Scadden DT. A cellular taxonomy of the bone marrow stroma in homeostasis and leukemia. Cell. 2019 177 (7): 1915-1932. doi: 10.1016/j.cell.2019.04.040. IF: 38.637.

10. Ortinau L, Wang H, Lei K, Deveza L, Jeong Y, Hara Y, Grafe I, Rosenfeld SB, Lee D, Lee B, Scadden DT and Park D. Identification of Functionally Distinct Mx1+αSMA+ Periosteal Skeletal Stem Cells. Cell Stem Cell. 2019 25 (6): 784-796. doi: 10.1016/j.stem.2019.11.003. IF: 20.860.

11. Lee S, Micalizzi D, Truesdell SS, Bukhari SIA, Boukhali M, Lombardi-Story J, Kato Y, Choo MK, Dey-Guha I, Ji F, Nicholson BT, Myers DT, Lee D, Mazzola MA, Raheja R, Langenbucher A, Haradhvala NJ, Lawrence MS, Gandhi R, Tiedje C, Diaz-Mu?oz MD, Sweetser DA, Sadreyev R, Sykes D, Haas W, Haber DA, Maheswaran S, Vasudevan S. A post-transcriptional program of chemoresistance by AU-rich elements and TTP in quiescent leukemic cells. Genome Biol. 2020 21 (1): 33. doi: 10.1186/s13059-020-1936-4. IF: 10.806.

12. Park JH, Lee NK, Lim HJ, Ji ST, Kim YJ, Jang WB, Kim DY, Kang S, Yun J, Ha JS, Kim H, Lee D†, Baek SH† and Kwon SM†. Pharmacological inhibition of mTOR attenuate replicative cell senescence and improve cellular function via regulating the STAT3-PIM1 axis in human cardiac progenitor cells. Exp Mol Med. 2020 52 (4): 615-628. doi: 10.1038/s12276-020-0374-4. IF: 5.418. †Corresponding authors.

13. Yusuf RZ, Saez B, Sharda A, Gastel NV, Yu VWC, Barywano N, Scadden EW, Acharya S, Chattophadhyay S, Huang C, Viswanathan V, S’Aulis D, Cobert J, Sykes DB, Keibler MA, Das S, Hutchinson JN, Churchill M, Mukherjee S, Lee D, Mercier F, Doench J, Bullinger L, Logan D, Schreiber S, Stephanopoulos G, Rizzo WB and Scadden DT. Aldehyde dehydrogenase 3a2 protects AML cells from oxidative death and the synthetic lethality of ferroptosis inducers. Blood. 2020 136 (11): 1303-1316. doi: 10.1182/blood.2019001808. IF: 17.543.