주요 연구 분야

자가면역질환 (류마티스 관절염, 강직성 척추염, 전신경화증), 염증, 손상연관분자패턴 (DAMPs), NETosis, 시트룰린화

연구 내용

우리 연구실에서는 대식세포, 중성백혈구, 그리고 다양한 질환 동물모델 및 환자 샘플을 이용하여 염증을 유발하는 물질 (DAMPs)을 동정하고 그 기능을 규명함으로써 류마티스 관절염이나 강직성 척추염과 같은 염증성 자가면역질환의 발병 메커니즘을 이해하고 이들 질환의 진단과 치료에 기여하고자 한다. 우리 연구실에서는 다음과 같은 다양한 기초 및 중개 연구를 수행하고 있다. 1) 류마티스 관절염과 강직성 척추염의 염증유발 물질 규명, 2) 대식세포에서 염증반응 조절 신규 단백질 발굴, 3) 다양한 자가면역 질환의 새로운 바이오마커 발굴, 4) 죽상동맥경화에 기여하는 염증 유발 물질 규명, 5) 전신경화증 치료제 후보물질 발굴, 6) 염증과 종양 유발에 있어 ubiquitin-like modifier의 역할 규명.

주요 연구 업적

1. Lee HN, Kim A, Kim Y, Kim GT, Sohn DH, Lee SG. Higher serum uric acid levels are associated with reduced risk of hip osteoporosis in postmenopausal women with rheumatoid arthritis. Medicine (Baltimore). 2020 Jun 12;99(24):e20633.

2. Lee B, Song YS, Rhodes C, Goh TS, Roh JS, Jeong H, Park J, Lee HN, Lee SG, Kim S, Kim M, Lee SI, Sohn DH*, Robinson WH*. Protein phosphatase magnesium-dependent 1A induces inflammation in rheumatoid arthritis. Biochem Biophys Res Commun. 2020 Feb 12;522(3):731-735. (*Equal contribution)

3. Kragstrup TW, Sohn DH, Lepus CM, Onuma K, Wang Q, Robinson WH, Sokolove J. Fibroblast-like synovial cell production of extra domain A fibronectin associates with inflammation in osteoarthritis. BMC Rheumatol. 2019 Dec 2;3:46.

4. Ha M, Jeong H, Roh JS, Lee B, Han ME, Oh SO, Sohn DH*, Kim YH*. DYSF expression in clear cell renal cell carcinoma: A retrospective study of 2 independent cohorts. Urol Oncol. 2019 Oct;37(10):735-741. (*Equal contribution)

5. Wang Q, Onuma K, Liu C, Wong H, Bloom MS, Elliott EE, Cao RR, Hu N, Lingampalli N, Sharpe O, Zhao X, Sohn DH, Lepus CM, Sokolove J, Mao R, Cisar CT, Raghu H, Chu CR, Giori NJ, Willingham SB, Prohaska SS, Cheng Z, Weissman IL, Robinson WH. Dysregulated integrin αVβ3 and CD47 signaling promotes joint inflammation, cartilage breakdown, and progression of osteoarthritis. JCI Insight. 2019 Sep 19;4(18). e128616.

6. Sohn DH*, Nguyen TT*, Kim S, Shim S, Lee S, Lee Y, Jhun H, Azam T, Kim J, Kim S. Structural characteristics of seven IL-32 variants. Immune Netw. 2019 Apr;19(2):e8. (*Equal contribution)

7. Park YJ, Park B, Lee M, Jeong YS, Lee HY, Sohn DH, Song JJ, Lee JH, Hwang JS, Bae YS. A novel antimicrobial peptide acting via formyl peptide receptor 2 shows therapeutic effects against rheumatoid arthritis. Sci Rep. 2018 Oct 2;8(1):14664

8. Roh JS, Sohn DH. Damage-associated molecular patterns in inflammatory diseases. Immune Netw. 2018 Aug 13;18(4):e27

9. Sohn DH, Jeong H, Roh JS, Lee HN, Kim E, Koh JH, Lee SG. Serum CCL11 level is associated with radiographic spinal damage in patients with ankylosing spondylitis. Rheumatol Int. 2018 Aug;38(8):1455-1464

10. Sohn DH. NETosis in autoimmune diseases. J Rheum Dis. 2016 Apr;23(2):82-87.

11. Sohn DH, Rhodes C, Onuma K, Zhao X, Sharpe O, Gazitt T, Shiao R, Fert-Bober J, Cheng D, Lahey LJ, Wong HH, Van Eyk J, Robinson WH, Sokolove J. Local joint inflammation and histone citrullination in a murine model of the transition from preclinical autoimmunity to inflammatory arthritis. Arthritis Rheumatol. 2015 Nov;67(11):2877-87