주요 연구 분야

시스템 독성학

점막면역학 및 마이크로바이옴학

연구 내용

1. Gut Exposome(네트워크독성): 환경 및 식이 노출의 최전선인 점막 특히 소화기 점막장벽은 점막 면역시스템의 핵심적 인식 영역이다. 이들 점막장벽 환경 및 마이크로바이오타, 식이대사체, 미생물독소 등 생물 화학적 요인과 숙주요인과의 상호작용을 생물정보학적 방법을 융합한 통합적으로 분석 예측.

2. Mucosal Network(병태스트레스 수리정보해석): 점막 환경 스트레스의 세포 감지자로서 리보솜은 통합스트레스 반응(ISR)의 핵심적 세포 네트워크 기구이다. 특히 점막에서의 미생물 및 화학노출체에 의한 점막 면역반응 및 장벽환경구성에 있어 리보솜 ISR 네트워크를 수리 정보시스템 기반의 질환병태경로(Adverse Outcome Pathway) 규명.

주요 연구 업적

1. Park, SH., Kim, J., and Moon, Y. Caveolar communication with xenobiotic-stalled ribosomes compromises gut barrier integrity. Communications Biology (2020). 3 (1): 270.

2. Kim, KH., Lee, SJ., Kim, J., and Moon, Y. Dynamic Malignant Wave of Ribosome-insulted Gut Niche via the Wnt-CTGF/CCN2 Circuit. iScience (2020). 23(5): 101076.

3. Yu M, Kim J, Ahn JH, Moon Y. Nononcogenic restoration of the intestinal barrier by E. coli-delivered human EGF. (2019). Journal of Clinical Investigation (JCI)/Insight 4 (16). e125166.

4. Park SH, Kim J, Yu M, Park JH, Kim YS, Moon Y. Epithelial Cholesterol Deficiency Attenuates Human Antigen R-linked Pro-inflammatory Stimulation via an SREBP2-linked Circuit (2016). J Biol Chem. 291(47):24641.

5. Oh CK, Park SH, Kim, J., Moon Y. Non-mutagenic Suppression of Enterocyte Ferroportin-1 by Chemical Ribosomal Inactivation via p38 MAPK-mediated Regulation: Evidences for Environmental Hemochromatosis (2016). J Biol Chem. 291(38):19858.

6. Choi, HJ, Do KH, Park, JH, Kim, J, Park SH, Yu, M, Moon Y. Early Epithelial Restitution by Nonsteroidal Anti-Inflammatory Drug?Activated Gene 1 Counteracts Intestinal Ulcerative Injuries (2016). J. of Immunology. 197(4):1415.

7. Do KH, Park SH, Kim J, Yu M, Moon Y. Ribosome Inactivation Leads to Attenuation of Intestinal Polymeric Ig Receptor Expression via Differential Regulation of Human Antigen R (2016). J. of Immunology. 197(3):847.

8. Oh CK, Lee SJ, Park SH, Moon Y. Acquisition of Chemoresistance and Other Malignancy-related Features of Colorectal Cancer Cells Are Incremented by Ribosome-inactivating Stress (2016). J Biol Chem. 291(19):10173.

9. Park SH, Choi HJ, Do KH, Kim J, Moon Y. Activating Transcription Factor 3-mediated Chemo- intervention with Cancer Chemokines in a Non-Canonical Pathway under Endoplasmic Reticulum Stress (2014) J Biol Chem. 289(39):27118.

10. Park, SH, Do, KH, Choi, HJ, Kim, J, Kim, K, Park, J, Oh, CG, and Moon, Y. Novel Regulatory Action of Ribosomal Inactivation on Epithelial Nod2-linked Pro-inflammatory Signals in Two Convergent ATF3- associated Pathways. (2013). Journal of Immunology 191(10), 5170-5180.

11. Choi, HJ, Kim, J., Do, KH, Park, S., and Moon, Y. Enteropathogenic Escherichia coli-induced macrophage inhibitory cytokine 1 mediates cancer cell survival: An in vitro implication of infection-linked tumor dissemination (2013). Oncogene 32 (41), 4960-4969.

12. Do, KH, Choi, HJ, Kim, J, Park, SH, Kim, KH, and Moon. Y. Suppressor of cytokine signaling 3 regulates B cell activating factor in human enterocytes under ribosomal stress. (2013). J. of Immunology 190(12), 6501.